Switch medication from clomipramine to imipramine.[1]
[2]
Stop clomipramine
- Gradually reduce dosage of clomipramine to a maximum of 75 mg/day.
- When a dosage of 75 mg/day is reached, stop administration.
Start imipramine
- No wash-out period is needed.
- Start administration of imipramine the next day in a normal dosage of 50-100 mg/day.
More information
- Both drugs are a TCA with anticholinergic properties, so a switch to a relatively high starting dose can be made.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. Nevertheless, mistakes and omissions cannot be entirely excluded. No rights devolve from the information provided. The editors and other providers of information to this site accept no responsibility for the content of this site or for the information provided therein; neither do they accept responsibility for possible damages which may derive from the use of the information on this site or from the linked sites. The editorial board accepts no responsibility for the content of the (linked) sites, for access to them, or for the products and services on these sites, nor for the occurrence of errors, viruses, and/or disruptions in service.
Stop clomipramine 
Start imipramine
More information