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Switch medication from amitriptyline to duloxetine.[1] [2]
Stop amitriptyline - Day 0: gradually reduce dosage of amitriptyline to a maximum of 50-100 mg/day, when this dosage is > 100 mg/day.
- Day 1-7: reduce dosage of amitriptyline to 25-50 mg/day.
- Day 8: stop administration of amitriptyline.
Start duloxetine- Day 8-14: a wash-out period of one week is necessary.
- Day 15: start administration of duloxetine in a normal dosage of 60 mg/day.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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