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Amitriptyline-duloxetine

Revision as of 18:54, 3 May 2009 by Alexandra (talk | contribs)
Amitriptyline
Type Antidepressant
Group TCA
links
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline
Duloxetine
Type Antidepressant
Group SNRI
links
Medscape Duloxetine
PubChem 60835
PubMed Duloxetine
Kompas (Dutch) Duloxetine
Wikipedia Duloxetine

Switch medication from amitriptyline to duloxetine.[1] [2]

Nietinrijdenbord.png Stop amitriptyline
  • Day 0: gradually reduce dosage of amitriptyline to a maximum of 50-100 mg/day, when this dosage is > 100 mg/day.
  • Day 1-7: reduce dosage of amitriptyline to 25-50 mg/day.
  • Day 8: stop administration of amitriptyline.
Eenrichtingbord.png Start duloxetine
  • Day 8-14: a wash-out period of one week is necessary.
  • Day 15: start administration of duloxetine in a normal dosage of 60 mg/day.


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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