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{{:lamotrigine
General information
Combination
CautionAbrupt stop of carbamazepine can cause serious lamotrigine rash as lamotrigine levels increase. [5] }} | ||||||||||||||||||||||||||||||||||||||
Adding lamotrigine
Contents
General information
- Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.
- Lamoptrigine is principally metabolised by UDP-glucuronosyltransferases.
- This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels.
Combination
- Carbamazepine can reduce lamotrigine serum concentration considerably. Add lamotrigine according to the general dosing advice.
Caution
Abrupt stop of carbamazepine can cause serious lamotrigine rash as lamotrigine levels increase. [5] to carbamazepine.
General information- Carbamazepine is principally metabolized by CYP3A4, and is a potent inducer of CYP1A2, CYP2C9, CYP3A4 and UDP-glucuronosyltransferases.
- ↑ WHO Collaborating Centre for Drug Statistics Methodology ATC=N03AF01
- ↑ Farmacotherapeutisch Kompas; Toxicologie (dutch)
- ↑ Farmacotherapeutisch Kompas - carbamazepine (dutch)
- ↑ KNMP; Informatorium Medicamentorum 2023; Monografie "carbamazepine" (Dutch)
- ↑ [http://www.ncbi.nlm.nih.gov/pubmed/12648898 Koch HJ et al. Clinically relevant reduction of lamotrigine concentrations by carbamazepine. J Clin Psychiatry 2005;66:400-1]
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[[Category:Combi-lamotrigine
General information
- Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.
- Lamoptrigine is principally metabolised by UDP-glucuronosyltransferases.
- This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels.
Combination
- Carbamazepine can reduce lamotrigine serum concentration considerably. Add lamotrigine according to the general dosing advice.
Caution
Abrupt stop of carbamazepine can cause serious lamotrigine rash as lamotrigine levels increase. [5]]]