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Adding olanzapine to topiramate.
General information- Topiramate induces CYP3A4 and is an inhibitor of CYP2C19.
- Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
- Topiramate induces CYP3A4 and is an inhibitor of CYP2C19.
- Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
- This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
Start olanzapine- Start olanzapine according general dosing advice.
Cave- Caution is advised when topiramate is prescribed with other drugs that predispose patients to heat-related disorders, including carbonic anhydrase inhibitors and drugs with anticholinergic activity. [5]
- ↑ 1.0 1.1 Farmacotherapeutisch Kompas - topiramaat (dutch)
- ↑ 2.0 2.1 2.2 2.3 KNMP; Informatorium Medicamentorum 2023; Monografie "olanzapine" (Dutch)
- ↑ Farmacotherapeutisch Kompas; Toxicologie (dutch)
- ↑ Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics; J Clin Psychiatry 2003;64:663-667
- ↑ Interactions between olanzapine and topiramate on drugs.com
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