Combining-Valproic acid-Gabapentin

Valproic acid Type moodstabilizer Group anticonvulsant links ATC-code N03AG01 PubChem 3121 PubMed acid%22 Valproic acid Drugs.com valproic-acid Kompas (Dutch) Valproic acid Wikipedia Valproic acid more info Cth 50000-100000μg/L Ctox 150000μg/L T1/2 10-15h bioavailability 100% administration O,R

Gabapentin Type moodstabilizer Group anticonvulsant links ATC-code N03AX12 PubChem 3446 PubMed Gabapentin Drugs.com gabapentin Kompas (Dutch) Gabapentin Wikipedia Gabapentin more info T1/2 5-7h bioavailability 60% administration O

Adding gabapentin to valproic acid.

General information

• Valproic acid is principally metabolized by CYP2C9, CYP2C19, CYP2A6 and UDP-glucuronosyltransferases. Valproic acid is an inhibitor of the enzymes CYP2C9, epoxide-hydroxylase and UDP-glucuronosyltransferases.
• Gabapentin is eliminated unchanged by the kidney for 100%.
• Valproic acid is principally metabolized by CYP2C9, CYP2C19, CYP2A6 and UDP-glucuronosyltransferases. Valproic acid is an inhibitor of the enzymes CYP2C9, epoxide-hydroxylase and UDP-glucuronosyltransferases.
• Gabapentine is eliminated unchanged by the kidney for 100%. Changes in the rate of excretion can cause unwanted effects.
• This combination of drugs may have possible synergistic effects. There are no reports for pharmacokinetic drug interactions. However, the combination will have additional side effects.

Start gabapentin

• Start gabapentin according to the general dosing advice.

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