Combining-Topiramate-Gabapentin
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Adding gabapentin to topiramate.
General information- Topiramate induces CYP3A4 and is an inhibitor of CYP2C19.
- Gabapentin is eliminated unchanged by the kidney for 100%.
- Topiramate induces CYP3A4 and is an inhibiter of CYP2C19.
- Gabapentine is eliminated unchanged by the kidney for 100%. Changes in the rate of excretion can cause unwanted effects.
- This combination of drugs may have possible synergistic effects. There are no reports for pharmacokinetic drug interactions. However, the combination will have additional side effects.
Start gabapentin- Start topiramate according to the general dosing advice.
- ↑ 1.0 1.1 1.2 Farmacotherapeutisch Kompas - topiramaat (dutch)
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