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Fluvoxamine-duloxetine

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Fluvoxamine
Type Antidepressant
Group SSRI
links
Medscape Fluvoxamine
PubChem 5324346
PubMed Fluvoxamine
Kompas (Dutch) Fluvoxamine
Wikipedia Fluvoxamine
Duloxetine
Type Antidepressant
Group SNRI
links
Medscape Duloxetine
PubChem 60835
PubMed Duloxetine
Kompas (Dutch) Duloxetine
Wikipedia Duloxetine

Switch medication from fluvoxamine to duloxetine.[1] [2]

Nietinrijdenbord.png Stop fluvoxamine
  • Before day 1: gradually reduce dosage of fluvoxamine to a maximum of 50 mg/day.
  • Day 1: stop fluvoxamine.
Eenrichtingbord.png Start duloxetine
  • Day 5: start duloxetine 30 mg/day.
  • Day 14: increase administration of duloxetine to 60 mg/day.
Infobord.png More information
  • Fluvoxamine inhibits the metabolism of duloxetine through CYP1A2.[3]
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
  1. ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. ↑ Lobo et al. In vitro and in vivo evaluations of cytochrome P450 1A2 interactions with duloxetine. Clin Pharmacokinet. 2008;47(3):191-202
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