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Adding risperidone to gabapentin.
General information- Gabapentin is eliminated unchanged by the kidney for 100%.
- Risperidone is principally metabolized by CYP2D6 to an active metabolite 9-OH-risperidone (paliperidone).
- This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels. Dose adaptation is recommended for this combination. [5]
Start risperidone- Start risperidone according to the general dosing advice.
Cave- Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects. [6]
- ↑ Farmacotherapeutisch Kompas - gabapentine (dutch)
- ↑ 2.0 2.1 KNMP; Informatorium Medicamentorum 2023; Monografie "risperidon" (Dutch)
- ↑ Woods SW; Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
- ↑ 4.0 4.1 The Lundbeck Institute; Psychotropics; Terminal Plasma Half-lives
- ↑ Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21
- ↑ Interactions between risperidone and gabapentin on drugs.com
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