Switch medication from bupropion to moclobemide.[1]
[2]
Stop bupropion
- Gradually reduce dosage of bupropion to a maximum of 150 mg/ day.
- When a dosage of 150 mg/day is reached, stop administration.
Start moclobemide
- Day 1-7: wash-out period of one week is necessary.
- Day 8: start normal dosage of moclobemide after this week, 300 mg/day.
More information
- By considering a wash-out period of one week (5 times the elimination time of bupropion and its metabolites) it is assured that all bupropion has left the body and no drug interactions occur.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop bupropion 
Start moclobemide
More information