Switch medication from vortioxetine to imipramine.[1]
[2]
Stop vortioxetine
- Day 1: reduce dosage of vortioxetine to 5 mg/day.
- Day 7: stop administration of vortioxetine.
Start imipramine
- Day 8: no wash-out period is needed. Start administration of imipramine in a low dosage of 25 mg/day.
- Day 15: increase dosage of imipramine.
- Start low, go slow.
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- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop vortioxetine 
Start imipramine
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