Switch medication from amitriptyline to vortioxetine.[1]
[2]
Stop amitriptyline
- Before day 1: gradually reduce dosage of amitriptyline to a maximum of 50 mg/day.
- Day 1: reduce dosage of amitriptyline to 25 mg/day.
- Day 8: stop administration of amitriptyline.
Start vortioxetine
- A wash-out period is not necessary.
- Start administration of vortioxetine the next day in a dosage of 10 mg/day.
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- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop amitriptyline 
Start vortioxetine
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