Switch medication from fluvoxamine to vortioxetine.[1]
[2]
Stop fluvoxamine
- Before day 1: gradually reduce dosage of fluvoxamine to a maximum of 50 mg/day, when this dosage is > 50 mg/day.
- Day 1: when a dosage of 50 mg/day is reached, stop administration
Start vortioxetine
- A wash-out period is not necessary, but care is needed.
- Day 1: start administration of vortioxetine in a dosage of 10 mg/day.
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- Fluvoxamine is a strong inhibitor of CYP2C9, which metabolizes vortioxetine.
- Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop fluvoxamine 
Start vortioxetine
More information