Switch medication from imipramine to vortioxetine.[1]
[2]
Stop imipramine
- Before day 1: gradually reduce dosage of imipramine to a maximum of 75 mg/day.
- Day 1: reduce dosage of imipramine to 50 mg/day.
- Day 1: reduce dosage of imipramine to 25 mg/day.
- Day 8: stop administration of imipramine.
Start vortioxetine
- A wash-out period is not necessary.
- Day 8: start administration of vortioxetine in a dosage of 10 mg/day.
More information
- Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop imipramine 
Start vortioxetine
More information