Switch medication from citalopram to vortioxetine.[1]
[2]
Stop citalopram
- Before day 1: Gradually reduce dosage of citalopram to a maximum of 20 mg/day, when this dosage is > 20 mg/day.
- Day 1: When a dosage of 20 mg/day is reached, stop administration.
Start vortioxetine
- A wash-out period is not necessary.
- Day 1: Start administration of vortioxetine in a dosage of 10 mg/day.
More information
- Citalopram is a weak inhibitor of CYP2D6, which metabolizes vortioxeine.
- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.[3]
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ European Medicines Agency | SmPC Brintellix 5 mg.
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Stop citalopram 
Start vortioxetine
More information