Switch medication from escitalopram to vortioxetine.[1]
[2]
Stop escitalopram
- Before day 1: gradually reduce dosage of escitalopram to a maximum of 10 mg/day, when this dosage is > 10 mg/day.
- Day 1: when a dosage of 10 mg/day is reached, stop administration
Start vortioxetine
- A wash-out period is not necessary, , but care is needed.
- Day 1: start administration of vortioxetine in a dosage of 10 mg/day.
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- Escitalopram is a weak inhibitor of CYP2D6, which metabolizes vortioxeine.
- Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop escitalopram 
Start vortioxetine
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