Switch medication from paroxetine to vortioxetine.[1]
[2]
Stop paroxetine
- Day -7: reduce dosage of paroxetine to 20 mg/day, if this dosage is > 20 mg/day.
- Day 0: dosage of paroxetine is 20 mg/day.
- Day 1: reduce dosage of paroxetine to 10 mg/day.
- Day 8: reduce dosage of paroxetine to 5 mg/day.
- Day 15: stop administration of paroxetine.
Start vortioxetine
- A wash-out period is not necessary.
- Day 15: start administration of vortioxetine in a normal dosage of 10 mg/day.
More information
- Paroxetine is a strong inhibitor of CYP2D6, which metabolizes vortioxetine.
- Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop paroxetine 
Start vortioxetine
More information