Switch medication from Aripiprazole to Lurasidon.[1]
[2]
Stop Aripiprazole
- Day 1-7: reduce the dose of aripiprazol to 50% of the dose.
- Day 14: stop administration of aripiprazol.
Start Lurasidon
- Day 1-7: start administration of lurasidon in a dosage of 40 mg/day.
- Day 8-14: increase the dose of lurasidon to 80 mg/day if necessary. Note: Continue the dose of lurasidone 40 mg/day if the patiënt is stable.
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- During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
- There is a possibility of QT interval prolongation.[3]
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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Stop Aripiprazole 
Start Lurasidon
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