Switch medication from vortioxetine to citalopram.[1]
[2]
Stop vortioxetine
- Day 1: reduce dosage of vortioxetine to 5 mg/day.
- Day 8: stop administration of vortioxetine.
Start citalopram
- No wash-out period is needed.
- Day 8: Start citalopram in a normal dosage of 20 mg/day.
More information
- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.[3]
- Due to the halflifes of both compounds, there will be automatic crosstapering in the body.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ European Medicines Agency. SmPC Brintellix 5 mg.
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Stop vortioxetine 
Start citalopram
More information