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Switch medication from duloxetine to nortriptyline.[1] [2]
Stop duloxetine - Before day 0: gradually reduce dosage of bupropion to a maximum of 60 mg/day.
- Day 1: reduce the dosage of duloxetine to 30 mg/day.
Start nortriptylineNo wash-out period is needed.
- Day 1: simultaneously start administration of nortriptyline in a low dosage of 25 mg/day.
- Day 8: stop administration of duloxetine and increase the dosage of nortriptyline to 50 mg/day.
More information- Duloxetine slows the metabolism of nortriptyline by CYP2D6.
- Caution is necessary at the start of administration of nortriptyline.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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