Switch medication from vortioxetine to fluoxetine.[1]
[2]
Stop vortioxetine
- Day 1: reduce dosage of vortioxetine to 5 mg/day.
- Day 8: stop administration of vortioxetine.
Start fluoxetine
- A wash-out period of 2 weeks is necessary, because of CYP2D6-inhibition.
- Day 22: start administration of fluoxetine in a normal dosage of 20 mg/day.
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- Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
- Fluoxetine is a strong inhibitor of CYP2D6, which metabolizes vortioxetine.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop vortioxetine 
Start fluoxetine
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