Switch medication from venlafaxine to clomipramine.[1]
[2]
Stop venlafaxine
- Day 0: gradually reduce dosage of venlafaxine to a maximum of 75 mg/ day.
- Day 1: reduce a dosage of 75 mg/day to 37,5 mg/day.
Start clomipramine
- Day 1: simultaneously start administration of clomipramine in a low dosage of 25-50 mg/day.
- Day 8: stop administration of venlafaxine and continue administration of clomipramine in a dosage of 50-75 mg/day.
More information
- “Start low, go slow” for clomipramine, and caution with this switch is necessary.
- Venlafaxine is a weak inhibitor of CYP2D6, which metabolizes clomipramine.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop venlafaxine 
Start clomipramine
More information