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Venlafaxine-imipramine

Revision as of 19:02, 5 May 2009 by Alexandra (talk | contribs) (Created page with '{{Drugswitch | from = venlafaxine | to = imipramine | stop = * '''Day 0:''' gradually reduce dosage of venlafaxine to a maximum of 75 mg/ day. * '''Day 1:''' reduce a dosage o...')
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Venlafaxine
Type Antidepressant
Group SNRI
links
Medscape Venlafaxine
PubChem 5656
PubMed Venlafaxine
Kompas (Dutch) Venlafaxine
Wikipedia Venlafaxine
Imipramine
Type Antidepressant
Group TCA
links
Medscape Imipramine
PubChem 3696
PubMed Imipramine
Kompas (Dutch) Imipramine
Wikipedia Imipramine

Switch medication from venlafaxine to imipramine.[1] [2]

Nietinrijdenbord.png Stop venlafaxine
  • Day 0: gradually reduce dosage of venlafaxine to a maximum of 75 mg/ day.
  • Day 1: reduce a dosage of 75 mg/day to 37,5 mg/day.
Eenrichtingbord.png Start imipramine
  • Day 1: simultaneously start administration of imipramine in a low dosage of 25 mg/day.
  • Day 8: stop administration of venlafaxine and continue administration of imipramine in a dosage of 50 mg/day.
Infobord.png More information
  • “Start low, go slow” for imipramine, and caution with this switch is necessary.
  • Venlafaxine is a weak inhibitor of CYP2D6, which metabolizes imipramine.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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