Switch medication from tranylcypromine to sertraline.[1]
[2]
Stop tranylcypromine
- Day 1: Decrease the original dose with about 25% every 3 days.
Start sertraline
- Day 28: Start and increase the dose with about 50% of the target dose per week.
More information
- After the last dose of tranylcypromine it takes about 14 days to restore the activity of the MAO enzymes
- Occurrence of the serotonin syndrome is possible without this wash-out period.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop tranylcypromine 
Start sertraline
More information