Switch medication from bupropion to hypericum.[1]
[2]
Stop bupropion
- Day 1: Stop bupropion.
- bupropion can be stopped abruptly for every dosage.[3]
Start hypericum
- Day 8: start administration of hypericum in a dosage of 300 mg three times a day (900 mg/day).[4][5][6]
More information
- Hypericum induces enzymes of the CYP P-450 type and P-gp type.
- Hypericum might have MAO-inhibiting and/or COMT-inhibiting properties.
- Many studies reported that hypericin is the main source of pharmacological effects of hypericum. However the IC50 of hypericin to inhibit MAO A and MAO B is 100- to 1000-fold higher than accessible Cmax values of hypericin after oral administration of hypericum.[7]
- No severe interactions are known.
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Stop bupropion 
Start hypericum
More information