Switch medication from hypericum to agomelatine.[1]
[2]
Stop hypericum
- Day 1: Stop hypericum.
- The administration of hypericum can be stopped abruptly.
Start agomelatine
- Day 2: Start administration of agomelatine in a dosage of 25 mg/day.
- If necessary, increase dosage of agomelatine to 50 mg/day.
More information
- No severe interactions are known.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop hypericum 
Start agomelatine
More information