Switch medication from hypericum to mirtazapine.[1]
[2]
Stop hypericum
- Day 1-14:Gradually decrease the dosage of hypericum.
- Day 15: stop administration of hypericum.
Start mirtazapine
- Day 15-22: a wash-out period of one week is necessary.
- Day 23: start administration of mirtazapine in a dosage of 15 mg/day.
- Day 30: increase dosage of mirtazapine to 30 mg/day.
- If necessary, increase dosage of mirtazapine further.
More information
- No severe interactions are known.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop hypericum 
Start mirtazapine
More information