Switch medication from mirtazapine to moclobemide.[1]
[2]
Stop mirtazapine
- Before day 1: Gradually reduce dosage of mirtazapine to a maximum of 30 mg/day, when this dosage is > 30 mg/day.
- Day 1: Reduce dosage of mirtazapine to 15 mg/day.
- Day 8: Stop administration of mirtazapine.
Start moclobemide
- Day 8-14: A wash-out period of one week is necessary.
- Day 15: Start administration of moclobemide 150 mg/day
- Day 23: ' Increase moclobemide dosage to 300 mg/day
More information
- Occurrence of serotonin syndrome is not very likely. For safety reasons a wash-out period (of one week) is considered.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop mirtazapine 
Start moclobemide
More information