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Switch medication from bupropion to venlafaxine.[1] [2]
Stop bupropion - Gradually reduce dosage of bupropion to a maximum of 150 mg/day.
- When a dosage of 150 mg/day is reached, stop administration
Start venlafaxine- Day 1-7: a wash-out period of at least one week is necessary.
- Day 8: start venlafaxine in a normal dosage of 37,5 mg or 75 mg (slow release) /day.
More information- By considering a wash-out period of one week (5 times the elimination time of bupropion and its metabolites) it is assured that all bupropion has left the body and no drug interactions occur.
- Bupropion slows the metabolism of venlafaxine by CYP2D6.[3]
.
- This switch is currently being reviewed.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ Kennedy et al, Combining bupropion SR with venlafaxine, paroxetine, or fluoxetine: a preliminary report on pharmacokinetic, therapeutic, and sexual dysfunction effects.. J Clin Psychiatry 2002 March;63(3):181-6.
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