Switch medication from venlafaxine to mianserine.[1]
[2]
Stop venlafaxine
- Day 0: gradually reduce dosage of duloxetine to a maximum of 75 mg/day.
- Day 1: reduce a dosage of venlafaxine from 75 mg/day to 37,5 mg/day.
Start mianserine
- Day 1: simultaneously start administration of mianserine in a dosage of 30 mg/day.
- Day 8: stop administration of venlafaxine and continue administration of mianserine only. If necessary, increase dosage of mianserine to 40-60 mg/day.
More information
- Venlafaxine is a weak inhibitor of CYP2D6, which metabolizes mianserine.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop venlafaxine 
Start mianserine
More information