Switch medication from mirtazapine to amitriptyline.[1]
[2]
Stop mirtazapine
- Before day 1: Gradually reduce dosage of mirtazapine to a maximum of 30 mg/day, when this dosage is > 30 mg/day.
- Day 1: Reduce dosage of mirtazapine to 15 mg/day.
- Day 8: Stop administration of mirtazapine.
Start amitriptyline
- Day 2: Start with normal dosage and increase with about 25% (up to 50%) every 3 days to target dose.
- Start administration of amitriptyline in a dosage of 50 mg/day.
More information
- No wash-out period is needed.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop mirtazapine 
Start amitriptyline
More information