Switch medication from bupropion to trazodone.[1]
[2]
Stop bupropion
- Day 1: Stop bupropion.
- bupropion can be stopped abruptly for every dosage.[3]
Start trazodone
- Day 2: Start with normal dosage and increase with about 25% (up to 50%) every 3 days to target dose.
- Start trazodone in a dosage of 100-150 mg/day.
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- No wash-out period is needed.
- Bupropion and its metabolites have long elimination times, so plasma concentrations will reduce gradually.
- Bupropion and its metabolites slow the metabolism of trazodone by CYP2D6.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ Multidisciplinair document Afbouwen Overige Antidepressiva 2023
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Stop bupropion 
Start trazodone
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