Switch medication from fluoxetine to tranylcypromine.[1]
[2]
Stop fluoxetine
- Before day 1: reduce dosage of fluoxetine with about 20 mg per week.
- Day 1: stop fluoxetine.
Start tranylcypromine
- Day 1-35: a wash-out period of five weeks is necessary because of the long half live.
- Day 36: start tranylcypromine in a low dosage of 20 mg/day for one week.
- Day 43: after this week gradually increase the dosage of tranylcypromine.
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- Desmethylfluoxetine has a half live of about one week so a long wash-out period is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop fluoxetine 
Start tranylcypromine
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