Switch medication from bupropion to clomipramine.[1]
[2]
Stop bupropion
- Gradually reduce dosage of bupropion to a maximum of 150 mg/ day.
- When a dosage of 150 mg/day is reached, stop administration.
Start clomipramine
- Day 1-3: start administration of clomipramine the next day in a low dosage of 25-50 mg/day.
- Day 4: increase dosage of clomipramine to 75 mg/day and continue slowly increasing the dosage depending on the condition of the patient.
More information
- Bupropion slows the metabolism of clomipramine via CYP2D6.
- Caution is necessary at the start of administration of clomipramine.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. Nevertheless, mistakes and omissions cannot be entirely excluded. No rights devolve from the information provided. The editors and other providers of information to this site accept no responsibility for the content of this site or for the information provided therein; neither do they accept responsibility for possible damages which may derive from the use of the information on this site or from the linked sites. The editorial board accepts no responsibility for the content of the (linked) sites, for access to them, or for the products and services on these sites, nor for the occurrence of errors, viruses, and/or disruptions in service.
Stop bupropion 
Start clomipramine
More information