Switch medication from bupropion to doxepin.[2]
[3]
Stop bupropion
- Gradually reduce dosage of bupropion to a maximum of 150 mg/ day.
- When a dosage of 150 mg/day is reached, stop administration.
Start doxepin
- Day 1-3: start administration of doxepin the next day in a low dosage of 25 mg/day.
- Day 4: increase dosage of doxepin to 50 mg/day and continue slowly increasing the dosage depending on the condition of the patient.
More information
- Bupropion slows the metabolism of doxepin via CYP2D6.
- Caution is necessary at the start of administration of doxepin.
- ↑ 1.0 1.1 1.2 1.3 1.4 KNMP; Informatorium Medicamentorum 2023; Monografie "doxepine" (Dutch)
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop bupropion 
Start doxepin
More information