Switch medication from paroxetine to trazodone.[1]
[2]
Stop paroxetine
- Before day 1: gradually reduce dosage of paroxetine to a maximum of 20 mg/ day, when this dosage is > 20 mg/day.
- Day 1: reduce dosage of paroxetine to 10 mg/day.
- Day 8: stop administration of paroxetine.
Start trazodone
- Day 9: start trazodone in dosage of 100-150 mg/day.
- If necessary, increase the dosage of trazodone every 3-4 days with 50 mg to a maximum of 400 mg/day.
More information
- Paroxetine slows the metabolism of trazodone via CYP2D6, so caution is necessary.
- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- This switch is currently being reviewed.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop paroxetine 
Start trazodone
More information