Switch medication from tranylcypromine to imipramine.[1]
[2]
Stop tranylcypromine
- Day 1: decrease the original dose with about 25% every 3 days.
- Day 9: stop administration of tranylcypromine.
Start imipramine
- Day 23: Start and increase the dose with about 25% of the target dose every 3 days. [3]
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- After the last dose of tranylcypromine it takes about 14 days to restore the activity of the MAO enzymes
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ KNMP; Informatorium Medicamentorum 2023; Monografie "tranylcypromine" (Dutch)
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Stop tranylcypromine 
Start imipramine
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