Switch medication from tranylcypromine to vortioxetine.[1]
[2]
Stop tranylcypromine
- Day 1: decrease the original dose with about 25% every 3 days.
- Day 9: stop administration of tranylcypromine.
Start vortioxetine
- A wash-out period of two weeks is necessary.
- Day 28: start administration of vortioxetine in a normal dosage of 10 mg/day. [3]
Cave
- Occurrence of the serotonin syndrome is possible without a wash-out period.
More information
Template:Restore
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ KNMP; Informatorium Medicamentorum 2023; Monografie "tranylcypromine" (Dutch)
The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. Nevertheless, mistakes and omissions cannot be entirely excluded. No rights devolve from the information provided. The editors and other providers of information to this site accept no responsibility for the content of this site or for the information provided therein; neither do they accept responsibility for possible damages which may derive from the use of the information on this site or from the linked sites. The editorial board accepts no responsibility for the content of the (linked) sites, for access to them, or for the products and services on these sites, nor for the occurrence of errors, viruses, and/or disruptions in service.
Stop tranylcypromine 
Start vortioxetine
Cave
More information