Switch medication from paroxetine to doxepin.[2]
[3]
Stop paroxetine
- Before day 1: gradually reduce dosage of paroxetine to a maximum of 20 mg/day when this dosage is > 20 mg/day.
- Day 1: reduce dosage of paroxetine to a maximum of 10 mg/day.
- Day 8: stop administration of paroxetine.
Start doxepin
- Day 9: start administration of doxepin in a low dosage of 25 mg/day.
- Day 16: continue administration of doxepin in a dosage of 50 mg/day.
More information
- An extra reduction week to paroxetine 2,5 mg/day sometimes is necessary.
- Low doses of paroxetine can be given by a paroxetine-solution.
- ↑ 1.0 1.1 1.2 1.3 1.4 KNMP; Informatorium Medicamentorum 2023; Monografie "doxepine" (Dutch)
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop paroxetine 
Start doxepin
More information