Switch medication from citalopram to trazodone.[1]
[2]
Stop citalopram
- Before day 1: gradually reduce dosage of citalopram to a maximum of 20 mg/day, when this dosage is > 20 mg/day.
- Day 1: reduce dosage of citalopram to a maximum of 10 mg/day.
- Day 8: stop administration of citalopram
Start trazodone
- No wash-out period is needed.
- Day 9: start trazodone in a dosage of 100-150 mg/day.
- If necessary, gradually increase the dosage of trazodone to a maximum of 400 mg/day.
More information
- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop citalopram 
Start trazodone
More information