Sertraline-duloxetine

Before day 1: Gradually reduce dosage of sertraline to a maximum of 50 mg/ day, when this dosage is > 50 mg/day.
Day 1: Reduce dosage of sertraline to a dosage of 25 mg/ day
Day 8: Stop administration of sertraline

Start duloxetine

No wash-out period is needed.
Day 9: start duloxetine the next day in normal dosage of 60 mg/day.

More information

Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
Cross-tapered switch might be possible as well. ^[3]

↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
↑ Perahia DG et al. Switching to duloxetine from selective serotonin reuptake inhibitor antidepressants: a multicenter trial comparing 2 switching techniques. J. Clin. Psychiatry 2008 Jan;69(1):95-105

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[1] Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules

[2] Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.

[SSRI_to_dulo-3] Perahia DG et al. Switching to duloxetine from selective serotonin reuptake inhibitor antidepressants: a multicenter trial comparing 2 switching techniques. J. Clin. Psychiatry 2008 Jan;69(1):95-105

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Sertraline-duloxetine

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