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Switch medication from dosulepine to agomelatine.[1] [2]
Stop dosulepine - Before day 1: gradually reduce dosage of dosulepine to a maximum of 75 mg/ day, when this dosage is > 75 mg/day.
- Day 1: reduce dosage of dosulepine to 50 mg/day.
- Day 8: reduce dosage of dosulepine to 25 mg/day.
- Day 15: stop administration of dosulepine.
Start agomelatine- Day 1: simultaneously start administration of agomelatine in a dosage of 25 mg/day.
- Day 15: continue administration of agomelatine. If necessary, increase dosage of agomelatine to 50 mg/day. [3]
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102
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