Switch medication from amitriptyline to venlafaxine.[1]
[2]
Stop amitriptyline
- Day 0: gradually reduce dosage of amitriptyline to a maximum of 50-100 mg/ day, when this dosage is > 100 mg/day.
- Day 1-7: reduce dosage of amitriptyline to 25-50 mg/day.
- Day 8: stop administration of amitriptyline.
Start venlafaxine
- Day 8-14: a wash-out period of one week is necessary.
- Day 15: Start administration of venlafaxine in a normal dosage of 37,5 mg or 75 mg (slow release) /day.
More information
- This switch is currently being reviewed.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop amitriptyline 
Start venlafaxine
More information