Switch medication from dosulepine to trazodone.[1]
[2]
Stop dosulepine
- Before day 1: gradually reduce dosage of dosulepine to a maximum of 75 mg/ day, when this dosage is > 75 mg/day.
- Day 1: reduce dosage of dosulepine to 25 mg/day.
- Day 8: stop administration of dosulepine .
Start trazodone
- Day 9: start administration of trazodone in a dosage of 100-150 mg/day.
- Day 16: increase administration of trazodone.
More information
- Occurrence of the serotonin syndrome is theoretically possilble, so caution is necessary.
- This switch is currently being reviewed.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop dosulepine 
Start trazodone
More information