Switch medication from clomipramine to moclobemide.[1]
[2]
Stop clomipramine
- Before day 0: gradually reduce dosage of clomipramine to a maximum of 75 mg/ day.
- Day 1-7: reduce dosage of clomipramine to 30 mg/day.
- Day 8: stop administration of clomipramine.
Start moclobemide
- Day 8-14: a wash-out period of one week is necessary.
- Day 15: start administration of moclobemide in a dosage of 150 mg/day.
- Day 18: increase dosage of moclobemide to 300 mg/day.
More information
- Caution with this switch is necessary, and the wash-out period in particular is important.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop clomipramine 
Start moclobemide
More information