Switch medication from nortriptyline to paroxetine.[1]
[2]
Stop nortriptyline
- Day 1: reduce dosage to 50%.
- Day 8: stop
Start paroxetine
- Day 1: simultaneously start administration of paroxetine in a low dosage of 10 mg/day.
- Day 8: stop administration of nortriptyline and continue administration of paroxetine in a dosage of 20 mg/day.
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- Paroxetine is a strong inhibitor of CYP2D6, which metabolizes nortriptyline.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop nortriptyline 
Start paroxetine
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