Switch medication from duloxetine to escitalopram.[1]
[2]
Stop duloxetine
- Gradually reduce dosage of duloxetine to a maximum of 60 mg/day.
- When a dosage of 60 mg/day is reached, stop administration.
Start escitalopram
- No wash-out period is needed.
- Start escitalopram the next day in a normal dosage of 10 mg/day.
More information
- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- This switch is currently being reviewed.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop duloxetine 
Start escitalopram
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