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Switch medication from trazodone to clomipramine.[1] [2]
Stop trazodone - Before day 1: gradually reduce dosage of trazodone to a maximum of 150-200 mg/day, when this dosage is > 150 mg/day.
- Day 1: reduce dosage of trazodone to 75-100 mg/day.
- Day 8: stop administration of trazodone.
Start clomipramineNo wash-out period is needed.
- Day 8: start administration of clomipramine in a dosage of 50 mg/day.
- Day 15: increase dosage of clomipramine to 75 mg/day.
- Start low, go slow.
More information- Occurrence of the serotonin syndrome is theoretically possible, so care is needed.
- The content of trazodone in the tablet, for example 100 mg or 150 mg, determines which exact doses are given.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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- This switch is currently being reviewed.