Switch medication from imipramine to duloxetine.[1]
[2]
Stop imipramine
- Before day 1: gradually reduce dosage of imipramine to a maximum of 75 mg/day.
- Day 1: reduce dosage of imipramine to 50 mg/day.
- Day 3: reduce dosage of imipramine to 25 mg/day.
Start duloxetine
- Day 4: simultaneously start administration of duloxetine in a normal dosage of 60 mg/day.
- Day 8: stop administration of imipramine and continue administration of duloxetine.
More information
- Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
- Duloxetine is a inhibitor of CYP2D6, which metabolizes imipramine.
- This switch is currently being reviewed.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. Nevertheless, mistakes and omissions cannot be entirely excluded. No rights devolve from the information provided. The editors and other providers of information to this site accept no responsibility for the content of this site or for the information provided therein; neither do they accept responsibility for possible damages which may derive from the use of the information on this site or from the linked sites. The editorial board accepts no responsibility for the content of the (linked) sites, for access to them, or for the products and services on these sites, nor for the occurrence of errors, viruses, and/or disruptions in service.
Stop imipramine 
Start duloxetine
More information