Switch medication from clomipramine to hypericum.[1]
[2]
Stop clomipramine
- Before day 1: gradually reduce dosage of clomipramine to a maximum of 75 mg/ day, when this dosage is > 75 mg/day.
- Day 1-3: reduce dosage of clomipramine to 50 mg/day.
- Day 4-7: reduce dosage of clomipramine to 25 mg/day.
- Day 8: stop administration of clomipramine.
Start hypericum
- Day 8-15: a wash-out period of one week is necessary.
- Day 16: start administration of hypericum in a dosage of 300 mg three times a day (900 mg/day).
Cave
More information
Template:Hypericuminfo
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop clomipramine 
Start hypericum
Cave
More information