Switch medication from vortioxetine to bupropion.[1]
[2]
Stop vortioxetine
- Day 1: reduce dosage of vortioxetine to 5 mg/day.
- Day 8: stop administration of vortioxetine.
Start bupropion
- Day 9: start administration of bupropion in a dosage of 150 mg/day.
More information
- Bupropion is a strong inhibitor of CYP2D6, which metabolizes vortioxetine. Combination of vortioxetine and bupropion can lead to adverse effects of vortioxetine.
- Vortioxetine has a biological half-life of 66 hours. Reduction to the lowest effective dose of vortioxetine probably prevents adverse effects of vortioxetine due to lower blood levels of vortioxetine. After 1 week at 5 mg vortioxetine, interaction with bupropion will not be dangerous.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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Stop vortioxetine 
Start bupropion
More information